PIEZO1 ELISA Kit for Human(Homo sapiens) | EIAab.comPIEZO1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PIEZO1(Gene name) > Human

PIEZO1 (Gene name),

Piezo-type mechanosensitive ion channel component 1 (Protein name ), PIEZ1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIEZO1(FAM38A;KIAA0233);

Protein name:

Piezo-type mechanosensitive ion channel component 1;

Alternative:

Protein FAM38A;Membrane protein induced by beta-amyloid treatment(Mib);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2521

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2521:

AKLIFLYRSP | ETMIKWTREK | E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q92508

MIM:

194380

KEGG:

hsa:9780

MIM:

611184

STRING:

9606.ENSP00000301015

Pfam:

PF12166

UniGene:

Hs.377001

Uniprot:

Q92508

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ELISA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227h

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96T

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ELISA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227r

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96T

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ELISA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227m

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Manual:

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96T

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CLIA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227m

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Piezo-type mechanosensitive ion channel component 1

Protein for Human Piezo-type mechanosensitive ion channel component 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes."
Satoh K. , Hata M. , Takahara S. , Tsuzaki H. , Yokota H. , Akatsu H. , Yamamoto T. , Kosaka K. , Yamada T.
Brain Res.1108:19-27(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-2521;TISSUE SPECIFICITY
3.

"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T. , Seki N. , Ishikawa K. , Ohira M. , Kawarabayasi Y. , Ohara O. , Tanaka A. , Kotani H. , Miyajima N. , Nomura N.
DNA Res.3:321-329(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-2521
tissue: Bone marrow.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-2521
5.

"Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis."
Zarychanski R. , Schulz V.P. , Houston B.L. , Maksimova Y. , Houston D.S. , Smith B. , Rinehart J. , Gallagher P.G.
Blood120:1908-1915(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 955-972; 1324-1334; 1548-1562 AND 1656-1671;VARIANTS DHS ARG-2225 AND HIS-2456;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1391; SER-1646 AND THR-1854;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2294
tissue: Leukemic T-cell.
9.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
10.

"Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum."
McHugh B.J. , Buttery R. , Lad Y. , Banks S. , Haslett C. , Sethi T.
J. Cell Sci.123:51-61(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1391 AND SER-1646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Piezo1 integration of vascular architecture with physiological force."
Li J. , Hou B. , Tumova S. , Muraki K. , Bruns A. , Ludlow M.J. , Sedo A. , Hyman A.J. , McKeown L. , Young R.S. , Yuldasheva N.Y. , Majeed Y. , Wilson L.A. , Rode B. , Bailey M.A. , Kim H.R. , Fu Z. , Carter D.A. , more...
Nature515:279-282(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
13.

"Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1."
Andolfo I. , Alper S.L. , De Franceschi L. , Auriemma C. , Russo R. , De Falco L. , Vallefuoco F. , Esposito M.R. , Vandorpe D.H. , Shmukler B.E. , Narayan R. , Montanaro D. , D'Armiento M. , Vetro A. , Limongelli I. , Zuffardi O. , Glader B.E. , Schrier S.L. , more...
Blood121:3925-3935(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DHS SER-718; SER-782; GLN-808; LEU-1117; ASP-2003; VAL-2020; MET-2127; 2166-LYS--LYS-2169 DEL; HIS-2456 AND GLN-2488;CHARACTERIZATION OF VARIANTS DHS HIS-2456 AND GLN-2488;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
14.

"Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels."
Albuisson J. , Murthy S.E. , Bandell M. , Coste B. , Louis-Dit-Picard H. , Mathur J. , Feneant-Thibault M. , Tertian G. , de Jaureguiberry J.P. , Syfuss P.Y. , Cahalan S. , Garcon L. , Toutain F. , Simon Rohrlich P. , Delaunay J. , Picard V. , Jeunemaitre X. , Patapoutian A.
Nat. Commun.4:1884-1884(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DHS PRO-1358; THR-2020; MET-2127 AND LEU-GLU-2496 INS;CHARACTERIZATION OF VARIANTS DHS PRO-1358; THR-2020; MET-2127; LEU-GLU-2496 INS; ARG-2225 AND HIS-2456
15.

"Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1."
Bae C. , Gnanasambandam R. , Nicolai C. , Sachs F. , Gottlieb P.A.
Proc. Natl. Acad. Sci. U.S.A.110:E1162-1168(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DHS ARG-2225 AND HIS-2456;CHARACTERIZATION OF VARIANTS DHS ARG-2225 AND HIS-2456;MUTAGENESIS OF ARG-2456
16.

"Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report."
Shmukler B.E. , Vandorpe D.H. , Rivera A. , Auerbach M. , Brugnara C. , Alper S.L.
Blood Cells Mol. Dis.52:53-54(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DHS HIS-2456
17.

"Recurrent mutation in the PIEZO1 gene in two families of hereditary xerocytosis with fetal hydrops."
Beneteau C. , Thierry G. , Blesson S. , Le Vaillant C. , Picard V. , Bene M.C. , Eveillard M. , Le Caignec C.
Clin. Genet.85:293-295(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DHS HIS-2456

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